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NEMBUTAL Sodium Solution (pentobarbital sodium injection) is a sterile solution for intravenous or intramuscular injection
Pentobarbital (Nembutal) is a short-acting barbiturate sedative-hypnotic that is widely used in veterinary practice for anaesthesia and euthanasia The sodium salts of amobarbital, pentobarbital, phenobarbital, and secobarbital are available as sterile parenteral solutions. You can Nembutal Phenobarbital UK ukbestpharma.com
For therapeutic purposes phenobarbital and phenobarbital sodium may be considered equivalent in effect.
See Epilepsy.
See Epilepsy and see also Prescribing and dispensing information.
See Epilepsy.
Avoid in Acute porphyrias; children; debilitated; elderly (in adults); history of alcohol abuse; history of drug abuse; respiratory depression (avoid if severe); seizures (may be exacerbated)
MHRA advises consider vitamin D supplementation in patients who are immobilised for long periods or who have inadequate sun exposure or dietary intake of calcium.
Phenobarbital may exacerbate seizures in patients with absence seizures, Dravet syndrome, and Lennox-Gastaut syndrome.
Agranulocytosis; anticonvulsant hypersensitivity syndrome; behaviour abnormal; bone disorders; bone fracture; cognitive impairment; confusion; depression; drowsiness; folate deficiency; hepatic disorders; memory loss; movement disorders; nystagmus; respiratory depression; severe cutaneous adverse reactions (SCARs); skin reactions; suicidal behaviours
Anxiety; hallucination; hypotension; megaloblastic anaemia; thrombocytopenia
Agitation; anaemia; aplastic anaemia; Dupuytren’s contracture; hypocalcaemia; irritability
For details on the management of poisoning, see Active elimination techniques, under Emergency treatment of poisoning.
Cross-sensitivity reported with carbamazepine.
Antiepileptic hypersensitivity syndrome associated with phenobarbital. See under Epilepsy for more information.
An increased risk of major congenital malformations and intra-uterine growth restriction, and possibility of adverse effects on neurodevelopment have been seen with phenobarbital, see Pregnancy in Epilepsy for further details.
Avoid if possible; drowsiness may occur.
Manufacturer advises caution in mild to moderate impairment; avoid in severe impairment.
Use with caution in mild to moderate impairment; avoid in severe impairment.
Plasma-phenobarbital concentration for optimum response is 15–40 mg/litre (60–180 micromol/litre); however, monitoring the plasma-drug concentration is less useful than with other drugs because tolerance occurs.
Avoid abrupt withdrawal (dependence with prolonged use).
For administration by mouth, tablets may be crushed.
For intravenous injection, dilute injection solution 1 in 10 with Water for Injections; give at a rate not more than 100 mg/minute.
For intravenous injection, dilute injection solution 1 in 10 with Water for Injections; give at a rate not more than 1 mg/kg/minute.
The RCPCH and NPPG position statement Choosing an Oral Liquid Medicine for Children states that recommended practice in the UK is to use an ethanol-free unlicensed 50 mg/5 mL liquid for the oral administration of phenobarbital to children when an oral liquid is required. Phenobarbital Elixir BP (15 mg/5 mL) contains 38% v/v of ethanol (alcohol), and so there is potential for accumulation when ingested repeatedly, especially in young children with low or immature metabolic capacity.
Different formulations of oral preparations may vary in bioavailability. Patients should be maintained on a specific manufacturer’s product.
https://www.medicinesforchildren.org.uk/medicines/phenobarbital-for-preventing-seizures/
There can be variation in the licensing of different medicines containing the same drug.
Forms available from special-order manufacturers include: tablet, capsule, oral suspension, oral solution.
View all medicinal forms and pricing information
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